Dutch painter, draughtsman, etcher and architect, He was one of eleven children of the landscape painter Frederick de Moucheron and Maria Magdalena de Jouderville, the daughter of the Rembrandt pupil Isaac de Jouderville, for whom he was named. He was apprenticed to his father, before going to Italy, where he arrived c. 1695 and stayed for at least two years. He worked mainly in Rome in company with other northern artists, who gave him the Bent-name 'Ordonantie'.
He specialized in vedute, such as View of the River Tiber (c. 1696; National Museum, Warsaw), which shows an atmospheric view of Rome from the south. In making Roman townscapes the main subject of his paintings he followed the singular example of Caspar van Wittel. Isaac also copied paintings by Nicolas Poussin and, on his return to Amsterdam in 1697, made a series of etchings after Gaspard Dughet. His interest in these classicist French masters had a clearly recognizable effect on his own work. He collaborated on larger projects with Jacob de Wit, and many of their collaborations still remain in the patrician homes where they were painted in Amsterdam.
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