Italian painter and caricaturist, son of the painter Giuseppe Ghezzi. He was the godson of Carlo Maratti.
He trained under his father, who was secretary of the Roman Accademia di San Luca, and Pier Leone joined the Academy in 1705. His essay painting, the Allegory of Gratitude, was donated to the institution for his admission, as was customary. He painted for various churches such as the Cappuccini in Frascati and San Onofrio in Urbino. Pier Leone is known for his frescoes in the Villa Falconieri in Frascati.
As a painter, his style changed quite much through the years, sometimes under the influence of French portraiture. His pen and gouache caricatures